Getting Started with EndeavorRx

Before your child begins EndeavorRx, consider these tips to help support you and your child through the treatment experience.

Make it a routine.

Try to build a committed routine with EndeavorRx as making this a habit may certainly help! Whether your child uses the treatment in the morning or afternoon, do whatever works best.

Expect to be challenged.

EndeavorRx will continuously adapt to your child’s gameplay performance, which can make the mechanics of the experience feel challenging. It’s important that your child expects that EndeavorRx may be difficult, and could even feel demotivating at times.

Cheer for your child!

Does your child need a bit of support or motivation with EndeavorRx? Play the role of a coach by providing guidance and encouragement when needed. It might help to regularly check-in with your child about the gameplay experience and discuss the benefits of using EndeavorRx.

Breaks are OK, effort is what matters!

It’s totally okay for your child to take an occasional break for a few minutes when using EndeavorRx. Even if a break is needed, it’s important to note that EndeavorRx requires effort. Remember: Great achievements take great effort!

Talk about treatment progress.

Talk to your child about the vibrant, imaginative worlds or interesting characters they’re discovering in the gameplay experience. And, use that moment to remind them of their progress by together looking at their completed missions and total orbs!

EndeavorRx is a commitment.

EndeavorRx is not for everyone. Compare it to learning to play an instrument or to speak a new language. It requires dedication and consistency – but it can be worth it. Chat with your child about this!

Reminders can help.

Make use of reminders in the treatment or in other tools you use for managing your family’s schedules, such as your calendar. These reminders may be just what you and your child need to stay on the treatment track!

If your child has unlocked all the worlds during treatment…

If your child has unlocked all of the worlds in EndeavorRx, it’s important to remember that the treatment is not yet over! EndeavorRx should be continually played as specifically recommended by your child’s healthcare professional. In fact, if your child has unlocked all the worlds before the treatment period has ended, your child can then play through their favorite worlds again, beat their previous scores, complete new quests, and unlock more costumes!

What can the EndeavorRx treatment journey look like?


  • You and your child download EndeavorRx.
  • You’re excited about EndeavorRx, and interested in how it may improve your child’s attention and focus.
  • You – together with your child – map out how EndeavorRx is going to fit into your family’s schedule and routine:

Do you have a designated place free from distractions for your child to play EndeavorRx?

  • If not, consider how you can minimize distractions.

What is the best time to play EndeavorRx?

  • Many people find it easier to play EndeavorRx at the same time each day to get into the habit of playing consistently. If that’s not possible, do what works best for you and your child.
  • It may help to make use of reminder functions in the treatment or in other tools you use for managing your schedule.


  • Your child is continually using EndeavorRx 5 days a week, approximately 25 minutes a day (or as directed by your child’s healthcare professional).
  • You’re speaking with your child about their treatment experience, especially if he/she starts to feel demotivated about playing. Whether it’s switching the time/place of treatment, using fun rewards, or just talking more about the experience, consider whatever works in keeping your child engaged with EndeavorRx.


  • You and your child may both notice improvements in your child’s attention as part of daily life.
  • And, check in with your child’s healthcare professional to determine the most appropriate treatment cadence moving forward – either during this first 3-month treatment period or the next.

EndeavorRx: Indications, Safety and Cautions

Indications for Use:
EndeavorRx is a digital therapeutic indicated to improve attention function as measured by computer-based testing in children ages 8-12 years old with primarily inattentive or combined-type ADHD, who have a demonstrated attention issue. Patients who engage with EndeavorRx demonstrate improvements in a digitally assessed measure, Test of Variables of Attention (TOVA®), of sustained and selective attention and may not display benefits in typical behavioral symptoms, such as hyperactivity. EndeavorRx should be considered for use as part of a therapeutic program that may include clinician-directed therapy, medication, and/or educational programs, which further address symptoms of the disorder.

Rx only: Federal law restricts this device to sale by or on the order of a physician. EndeavorRx should only be used by the patient for whom the prescription was written. For medical questions, please contact your child’s healthcare provider. If you are experiencing a medical emergency, please dial 911. EndeavorRx is not intended to be used as a stand-alone therapeutic and is not a substitution for your child’s medication.

If your child experiences frustration, emotional reaction, dizziness, nausea, headache, eye-strain, or joint pain while playing EndeavorRx pause the treatment. If the problem persists contact your child’s healthcare provider. If your child experiences a seizure stop the treatment and contact your child’s healthcare provider.

EndeavorRx may not be appropriate for patients with photo-sensitive epilepsy, color blindness, or physical limitations that restrict use of a mobile device; parents should consult with their child’s healthcare provider.

Please follow all of your mobile device manufacturer’s instructions for the safe operation of your mobile device. For example, this may include appropriate volume settings, proper battery charging, not operating the device if damaged, and proper device disposal. Contact your mobile device manufacturer for any questions or concerns that pertain to your device.

Of 538 participants using EndeavorRx, 50 participants (9.3%) experienced treatment-related adverse events (probable, likely), and three participants experienced treatment-related adverse events with the digital control, in studies where a control was used. EndeavorRx associated adverse events included frustration (6.1%), headache (1.3%), dizziness (0.6%), emotional reaction (0.4%), nausea (0.4%), and aggression (0.2%). There were no serious adverse events. All adverse events were generally transient. Only 3 events led to device discontinuation, and no subject reported lasting or irreversible effects after discontinuation.